Hydrochloric Acid → 2-Bromo-4-chlorobenzene-1-thiol

HRID 992486ノート

反応式

HRID 992486 の反応式
[Br:1][C:2]12[S:10][CH:3]1[CH:4]=[CH:5][C:6]1([Cl:9])S[CH:7]12.[BH4-].[Na+].CO.Cl>C1COCC1>[Br:1][C:2]1[CH:7]=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[SH:10]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 4311764Sodium borohydrideHCID 86586184HCID 86586184、化合物

生成物 1

HCID 218168372-Bromo-4-chlorobenzene-1-thiol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
23 °C

実験手順

A solution of 2-bromo-4-chlorobenzene disulfide (3.8 g, 8.5 mmol) in THF (30 mL) was treated with NaBH4 (0.83 g, 22.0 mmol). The mixture was refluxed for a while and treated with MeOH (2 mL); heating was resumed for 0.5 hours. Mixture was cooled to 23° C., acidified with HCl (3N) and extracted with Et2O. The Et2O extracts were dried over MgSO4, filtered, and the filtrate was concentrated in vacuo to afford the title compound which was used without further purification.

後処理

  1. temperatureThe mixture was refluxed for a while
  2. temperatureheating
  3. extractionextracted with Et2O
  4. dry with materialThe Et2O extracts were dried over MgSO4
  5. filtrationfiltered
  6. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-03e0bdca654d4eacb7e9d8b325fa90b4
出典データセット
uspto-grants-2002_10
特許番号
US06469042B1

反応ノート

読み込み中…