Pyrazole → 3-(1h-pyrazol-1-yl)benzaldehyde
反応式
[CH:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1)=[O:2].[NH:12]1[CH:16]=[CH:15][CH:14]=[N:13]1.N1C=CC=CC=1>ClCCl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[N:12]1([C:5]2[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=2)[CH:1]=[O:2])[CH:16]=[CH:15][CH:14]=[N:13]1参加物
6
実験手順
A mixture of 3-formylphenylboronic acid (2.00 g, 13.34 mmol), pyrazole (0.46 g, 6.67 mmol), copper(II) acetate (1.82 g, 10.01 mmol), pyridine (1.10 mL, 13.34 mmol), and powdered 4A molecular sieves (2.5 g) in dichloromethane (20 mL) was stirred under an air atmosphere for 24 h. The mixture was then filtered through Celite, the filtered solids were washed with MeOH, and the combined filtrate was concentrated. Purification by chromatography (SiO2, 3:1 hexane/ethyl acetate) yielded the title compound.
後処理
- filtrationThe mixture was then filtered through Celite
- washthe filtered solids were washed with MeOH
- concentrationthe combined filtrate was concentrated
- customPurification by chromatography (SiO2, 3:1 hexane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-3e66280fab2c44eea426045eb37f5b1e
- 出典データセット
- uspto-grants-2002_10
- 特許番号
- US06472372B1
反応ノート
読み込み中…