Hydrochloric Acid → 5-[3-(4-Methoxyphenyl)propionyl]barbituric acid

HRID 993051ノート

反応式

HRID 993051 の反応式
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20](Cl)=[O:21])=[CH:14][CH:13]=1.Cl>N1C=CC=CC=1>[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20]([CH:7]2[C:5](=[O:6])[NH:4][C:2](=[O:3])[NH:1][C:8]2=[O:9])=[O:21])=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6211Barbituric AcidHCID 109324413-(4-Methoxyphenyl)propionyl chloride

生成物 1

HCID 140406695-[3-(4-Methoxyphenyl)propionyl]barbituric acid収率 84.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a suspension of barbituric Acid (6.4 g) in 48 ml of pyridine are added dropwise 11 g of 3-(4-Methoxyphenyl)propionyl chloride and the mixture is stirred at room temperature for 18 hours. The reaction mixture is then poured into ice and acidified to pH=1 by adding 6 N hydrochloric acid. A solid precipitates, which is filtered and resuspended in methanol. The suspension is kept under stirring for 15 minutes, then the solid is recovered by filtration to give 12.2 g of the product m.p. 248-250° C.

後処理

  1. additionThe reaction mixture is then poured into ice
  2. customA solid precipitates
  3. filtrationwhich is filtered
  4. stirringunder stirring for 15 minutes
  5. filtrationthe solid is recovered by filtration

出典と根拠

ORDレコード
ord-636b6f65038640eebf739ef9c07fa20b
出典データセット
uspto-grants-2002_10
特許番号
US06472396B1

反応ノート

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