Fentanyl Citrate
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기본 정보
- CAS
990-73-8- 표준 SMILES
CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O- InChIKey
IVLVTNPOHDFFCJ-UHFFFAOYSA-N- 분자식
- C28H36N2O8
- 평균 분자량
- 528.6 g/mol
- 단동위원소 질량
- 528.24716611
개요
Fentanyl citrate is the citric acid salt of fentanyl, comprising equimolar amounts of citric acid and fentanyl. A -opioid receptor agonist, it is a potent opioid analgesic used in the management of labour pain, postoperative pain, and chronic intractable cancer pain. It is also widely used as the analgesic component of balanced anaesthesia. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It contains a fentanyl.
이름 및 식별자
- 우선 이름
- Fentanyl Citrate
- IUPAC
- 2-hydroxypropane-1,2,3-tricarboxylic acid;N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
이름 및 동의어
FENTANYL CITRATE990-73-8LeptanalOraletPhentanyl citrateActiqAbstralLazandaOnsolisInstanylFentanyl buccalMcN-JR-4263-49
이름 더 보기
Fentanyl citrate ciiSUBLIMAZE PRESERVATIVE FREEMUN5LYG46HN-(1-Phenethyl-4-piperidyl)propionanilide citrateFENTANYL CITRATE PRESERVATIVE FREEKw-2246N-(1-Phenethyl-4-piperidyl)propionanilide dihydrogen citrateN-(1-Phenethyl-4-piperidinyl)propionanilide dihydrogen citrate
데이터베이스 식별자
- CAS
990-73-8- PubChem CID
- 13810
- DTXSID
DTXSID80243933- ChEMBL
CHEMBL688- ChEBI
CHEBI:31602- UNII
- MUN5LYG46H
- EC Number
- 213-588-0
물성
구조 계산 물성보충 중
- 극성 표면적
- 156 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 11
- 무거운 원자 수
- 38
- 형식 전하
- 0
- 복잡도
- 618
실험 및 물리화학적 성질
Chemical ClassesOther Uses -> Pharmaceuticals
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine
FDA approved drugs -> Active ingredient
Animal DrugsActive Ingredients (Fentanyl Citrate) -> FDA Greenbook
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
P233, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 68 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationFentanyl citrate: HSNO Approval: HSR003800 Approved with controls
Other Safety InformationIMAP assessments - Propanamide, N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-,2-hydroxy-1,2,3-propanetricarboxylate (1:1): Environment tier I assessment
Hazards Summary
Fentanyl is a solid. It is a Schedule II controlled substance. Fentanyl citrate is a strong analgesic used preoperatively, during surgery, and in the immediate postoperative period for its analgesic action. . . . Introduced into clinical practice in the 1960s, the analgesic fentanyl is 100 times more potent than morphine. [HSDB] TLV Basis is CNS impairment and respiratory depression; [ACGIH TLVs and BEIs]
Hazard Classes and CategoriesAcute Tox. 2 (100%)
안전 및 보호
Threshold Limit Values (TLV)
0.00001, inhalable particulate matter (Surface Level = 1 ug/100cm2)
0.00002, inhalable particulate matter
독성 정보
화학 및 산업
약리 정보
FDA Pharmacological Classification
FENTANYL CITRATE
Opioid Agonist [EPC]; Full Opioid Agonists [MoA]
MeSH Pharmacological Classification
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
용도 및 제조
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
관련 반응
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