Fentanyl Citrate

HCID 13810CAS 990-73-8

기본 정보

표준 SMILES: CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
InChIKey: IVLVTNPOHDFFCJ-UHFFFAOYSA-N
분자식: C28H36N2O8
평균 분자량: 528.6 g/mol
단동위원소 질량: 528.24716611

개요

Fentanyl citrate is the citric acid salt of fentanyl, comprising equimolar amounts of citric acid and fentanyl. A -opioid receptor agonist, it is a potent opioid analgesic used in the management of labour pain, postoperative pain, and chronic intractable cancer pain. It is also widely used as the analgesic component of balanced anaesthesia. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It contains a fentanyl.

이름 및 식별자

우선 이름: Fentanyl Citrate
IUPAC: 2-hydroxypropane-1,2,3-tricarboxylic acid;N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide

이름 및 동의어

FENTANYL CITRATE990-73-8LeptanalOraletPhentanyl citrateActiqAbstralLazandaOnsolisInstanylFentanyl buccalMcN-JR-4263-49

이름 더 보기

Fentanyl citrate ciiSUBLIMAZE PRESERVATIVE FREEMUN5LYG46HN-(1-Phenethyl-4-piperidyl)propionanilide citrateFENTANYL CITRATE PRESERVATIVE FREEKw-2246N-(1-Phenethyl-4-piperidyl)propionanilide dihydrogen citrateN-(1-Phenethyl-4-piperidinyl)propionanilide dihydrogen citrate

데이터베이스 식별자

CAS: 990-73-8
PubChem CID: 13810
DTXSID: DTXSID80243933
ChEMBL: CHEMBL688
ChEBI: CHEBI:31602
UNII: MUN5LYG46H
EC Number: 213-588-0

물성

구조 계산 물성

극성 표면적: 156 Å²
수소 결합 공여자 수: 4
수소 결합 수용자 수: 9
회전 가능 결합 수: 11
무거운 원자 수: 38
형식 전하: 0
복잡도: 618

실험 및 물리화학적 성질

Chemical ClassesOther Uses -> Pharmaceuticals

Human Drugs · 3건

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Fentanyl Citrate) -> FDA Greenbook

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P233, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 68 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory InformationFentanyl citrate: HSNO Approval: HSR003800 Approved with controls

Other Safety InformationIMAP assessments - Propanamide, N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-,2-hydroxy-1,2,3-propanetricarboxylate (1:1): Environment tier I assessment

Hazards Summary · 1건

Fentanyl is a solid. It is a Schedule II controlled substance. Fentanyl citrate is a strong analgesic used preoperatively, during surgery, and in the immediate postoperative period for its analgesic action. . . . Introduced into clinical practice in the 1960s, the analgesic fentanyl is 100 times more potent than morphine. [HSDB] TLV Basis is CNS impairment and respiratory depression; [ACGIH TLVs and BEIs]

Hazard Classes and CategoriesAcute Tox. 2 (100%)

안전 및 보호

Threshold Limit Values (TLV) · 2건

0.00001, inhalable particulate matter (Surface Level = 1 ug/100cm2)

0.00002, inhalable particulate matter

독성 정보

Adverse EffectsACGIH Carcinogen - Not Classifiable.

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

FENTANYL CITRATE

Opioid Agonist [EPC]; Full Opioid Agonists [MoA]

MeSH Pharmacological Classification · 4건

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.

Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)