Mannitol → Fentanyl

HRID 8554

반응식

HRID 8554 반응식
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16].C(C(O)(C(O)=O)CC(O)=O)C(O)=O.COC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O>O>[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:28][CH2:29]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16]

참가 물질

5

반응물 3

HCID 6251MannitolHCID 13810Fentanyl CitrateHCID 134601Aspartame

생성물 1

HCID 3345Fentanyl

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Gelatin (765 g) and mannitol (540 g) were dispersed in a portion of purified water (16 kg) by mixing thoroughly in the bowl of a vacuum mixer. The mix was then heated to 40° C.±2° C. and homogenised for ten minutes to allow complete dissolution of the solids. The mix was cooled down to room temperature (20–24° C.). When cooled, the fentanyl citrate (22.68 g), the aspartame (90 g), and mint flavour (90 g) were added sequentially to the mix. The mix was then homogenized to ensure complete dissolution of the solids. The remaining water (492 g) was added to the mixer and the bulk mix homogenized to ensure dissolution was complete.

후처리

  1. additionby mixing thoroughly in the bowl of a vacuum mixer
  2. temperatureThe mix was then heated to 40° C.±2° C.
  3. dissolutiondissolution of the solids
  4. temperatureWhen cooled
  5. stirringThe mix was then homogenized
  6. dissolutiondissolution of the solids
  7. additionthe bulk mix
  8. stirringhomogenized
  9. dissolutiondissolution

출처 및 근거

ORD 기록
ord-7699baaddd76414b851d402dc61a2e83
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07090866B2

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