Magnesium Stearate → Naloxone Fentanyl
반응식
[CH3:1][CH2:2][C:3]([N:5]([CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[CH2:26]([C:30](O)([C:35]([OH:37])=O)[CH2:31][C:32]([OH:34])=O)[C:27]([OH:29])=O.[C:39]([O-])(=O)[CH2:40]CCCCCCCCCCCCCCCC.[Mg+2].C([O-])(=[O:78])CCCCCCCCCCCCCCCCC>>[CH2:12]=[CH:17][CH2:16][N:15]1[C@@H:18]2[CH2:19][C:20]3[CH:21]=[CH:22][C:23]([OH:78])=[C:32]4[O:34][C@H:26]5[C:27]([CH2:39][CH2:40][C@:35]2([OH:37])[C@:30]5([C:31]=34)[CH2:13][CH2:14]1)=[O:29].[CH3:1][CH2:2][C:3]([N:5]([CH:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:16][CH2:17]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4]참가 물질
3
실험 절차
Fentanyl citrate was added to the carrier material in amounts corresponding to a batch size of 300 tablets. Mixing was carried out under the same conditions as those described in Example 1. Croscarmellose sodium and silicified microcrystalline cellulose, and then magnesium stearate, were added and admixed under the same conditions as those described in Example 1.
후처리
- additionMixing
출처 및 근거
- ORD 기록
- ord-4dd9c14257d746a4973130c2e6fabeb5
- 출처 데이터셋
- uspto-grants-2014_09