Enprofylline (HCID 1676)

개요

Enprofylline is xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. It has a role as a non-steroidal anti-inflammatory drug, a bronchodilator agent, an anti-arrhythmia drug and an anti-asthmatic drug.

이름 및 식별자

우선 이름: Enprofylline
IUPAC: 3-propyl-7H-purine-2,6-dione
현지명: 엔프로필라인
영어명: ENPROFYLLINE
분자식: C8H10N4O2
분자량: 194.19

이름 및 동의어

ENPROFYLLINE41078-02-83-Propylxanthine3-n-PropylxanthineEnprofilinaEnprofyllinum3,7-Dihydro-3-propyl-1H-purine-2,6-dione1H-Purine-2,6-dione, 3,7-dihydro-3-propyl-D-4028DTXSID90451863-Propyl-3,7-dihydro-purine-2,6-dioneDT7DT5E518

이름 더 보기

엔프로필라인nilyphENPROPHYLLINEEnprofyllilie3-Propylxanthfine

3-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dioneD 4028DTXCID7025186CHEBI:126237RefChem:590853255-201-83-propyl-7H-purine-2,6-dioneEnprofilina [INN-Spanish]

데이터베이스 식별자

CAS: 41078-02-8
PubChem CID: 1676
DTXSID: DTXSID9045186
ChEMBL: CHEMBL279898
ChEBI: CHEBI:126237
UNII: DT7DT5E518
EC Number: 255-201-8
Nikkaji: J16.542E

물성

구조 계산 물성

XLogP: 0.3
극성 표면적: 78.1 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 3
회전 가능 결합 수: 2
무거운 원자 수: 14
형식 전하: 0
복잡도: 268

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15

LogP · 2건

-0.2

0.33

Solubility · 2건

5.68e+00 g/L

>29.1 [ug/mL] (The mean of the results at pH 7.4)

Melting Point · 2건

287-289 °C

287 - 289 °C

Physical DescriptionSolid

물리화학적 성질

녹는점: 287 · 287-289 °C
밀도: 1.38 g/cm3 · 1.38 g/cm3
저장 조건: 2 · 2-8°C
용해도: DMSO: 용해될 수 있다
물리적 상태: 고체
산도 계수 (pKa): 10.26 · 10.26±0.20(Predicted)
색상: 하얀색

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (100%)

안전 데이터

wgk: 3
rtecs: UO8439700
risk_code: 20/21/22
hazard_code: Xn
safety_code: 36

화학 및 산업

약리 정보

Protein Binding49%

PharmacodynamicsEnprofylline is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.

Mechanism of Action · 1건

Enprofylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.

Biological Half-Life1.9 hours

MeSH Pharmacological Classification · 3건

Agents that cause an increase in the expansion of a bronchus or bronchial tubes.

Drugs that are used to treat asthma.

Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS.

Absorption, Distribution and ExcretionRapidly absorbed from the digestive tract

응용 분야 · 2건

개요3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (Kis = 44, 32, and 6.3 μM for A1, A2A, and A2B, respectively) and cAMP phosphodiesterase (Ki = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.

용도Enprofylline is a xanthine lacking adenosine receptor antagonism.

상·하류 제품 정보

상류 원료

시안초산

공급사27 곳

北京华美互利生物化工010-56205725 · [email protected]

Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]

LGM Pharma1-(800)-881-8210 · [email protected]

武汉易泰科技有限公司上海分公司18930552037 · [email protected]

安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]

추가 설명 · 1건

정의ChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n uropathy.