Enprofylline → HCID 14014540, 화합물

HRID 620144

반응식

HRID 620144 반응식
[CH2:1]([N:4]1[C:12]2[N:11]=[CH:10][NH:9][C:8]=2[C:7](=O)[NH:6][C:5]1=[O:14])[CH2:2][CH3:3].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:16]>N1C=CC=CC=1>[CH2:1]([N:4]1[C:12]2[N:11]=[CH:10][NH:9][C:8]=2[C:7](=[S:16])[NH:6][C:5]1=[O:14])[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 1676EnprofyllineHCID 14817Phosphorus sulfide (P2S5)

생성물 1

HCID 14014540HCID 14014540, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매2회

실험 절차

A suspension of 9.32 g. (48 mM) of 3-propylxanthine in 80 ml. of pyridine, was treated with 17.33 g. (78 mM.) of phosphorus pentasulfide in 80 ml. of pyridine, and worked up analogously to Example I. 8.9 g. of 3-propyl-6-thioxanthine was obtained. Recyrstallization from methanol-acetone gave 7.4 g. (59% yield) of needles with a melting point of 249°-250° C.

후처리

  1. additionA suspension of 9.32 g

출처 및 근거

ORD 기록
ord-9f94ce3856e44840b57ffdc15b1a7150
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04820709

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