Hexasodium hexametaphosphate

Cosmetic ingredients (Sodium Hexametaphosphate) -> CIR (Cosmetic Ingredient Review)

Chelating

CLEAR, HYGROSCOPIC GLASS; MP 628 °C; SOL IN WATER, BUT DISSOLVES SLOWLY; DEPOLYMERIZES IN AQ SOLN TO FORM SODIUM TRIMETAPHOSPHATE & SODIUM ORTHOPHOSPHATES. /POLYMERIC SODIUM METAPHOSPHATES/

SOL IN WATER; INSOL IN ORG SOLVENTS. /SODIUM HEXAMETAPHOSPHATE DETERGENTS/

When heated to decomposition it emits toxic fumes of phosphoxides and Na2O.

WHEN HEATED TO DECOMP, CAN EMIT HIGHLY TOXIC FUMES OF PO(X).

It possesses sequestering, dispersing, and flocculating properties and precipitates proteins. In very low concentrations, it inhibits corrosion in steel and prevents the precipitation of slightly soluble, scale-forming compounds such as calcium carbonate and calcium sulfate. /Calgon/

Depolymerizes in aqueous soln to form sodium trimetaphosphate and sodium orthophosphates.

Miscible in water, but insoluble in organic solvents. /Calgon/

This chemical does not meet GHS hazard criteria for 100% (19 of 19) of all reports.

Not Classified

Aggregated GHS information provided per 19 reports by companies from 1 notifications to the ECHA C&L Inventory.

Chemical: Metaphosphoric acid (H6P6O18), hexasodium salt

Sodium hexametaphosphate: Does not have an individual approval but may be used under an appropriate group standard

Sodium hexametaphosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.

Sodium hexametaphosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Residues of sodium hexametaphosphate are exempted from the requirement of a tolerance when used as a surfactant, emulsifier, wetting agent, suspending agent, dispersing agent or buffer in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

EYE CONTACT WITH CONCENTRATED ALKALI CAUSES CONJUNCTIVAL EDEMA & CORNEAL DESTRUCTION. A. ALKALIES PENETRATE SKIN SLOWLY. EXTENT OF DAMAGE THEREFORE DEPENDS ON DURATION OF CONTACT. B. CHRONIC POISONING (FROM SKIN CONTACT). CHRONIC DERMATITIS MAY FOLLOW REPEATED CONTACT ... . /ALKALIES/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Residues of sodium hexametaphosphate are exempted from the requirement of a tolerance when used as a surfactant, emulsifier, wetting agent, suspending agent, dispersing agent or buffer in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/

The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Sodium Hexametaphosphate...

Safe for use in cosmetics, with qualifications

... /0.1% & 5% SOLN OF CALGON/ WERE FOUND MUCH TOO INJURIOUS TO USE FOR THE PURPOSE OF REMOVING CALCIUM FROM THE CORNEA. /CALGON/

NO HEALTH HAZARDS ARE ASSOCIATED WITH SODIUM HEXAMETAPHOSPHATE IN FOODS & NATURAL WATERS.

... /SODIUM/ SALTS, SUCH AS METAPHOSPHATES, ARE TOXIC PROBABLY BECAUSE OF THEIR EXCESS ALKALINITY RATHER THAN FROM SIMPLE SODIUM EXCESS. /SODIUM METAPHOSPHATES/

ACUTE POISONING BY INJESTION: ... EVEN THOUGH PATIENTS RECOVER FROM IMMEDIATE DAMAGE, ESOPHAGEAL STRICTURE CAN OCCUR WK, MO, OR YR LATER TO MAKE SWALLOWING DIFFICULT. INGESTION OF TRIPOLYPHOSPHATE ... IN ... DETERGENTS OR LAXATIVES CAUSE SHOCK-LIKE STATE, FALL OF BLOOD PRESSURE, SLOW PULSE, CYANOSIS COMA & SOMETIMES TETANY AS RESULT OF REDN IN IONIC CALCIUM. /ALKALIES/

For more Human Toxicity Excerpts (Complete) data for SODIUM HEXAMETAPHOSPHATE (7 total), please visit the HSDB record page.

A comprehensive examination of metal levels at various trophic levels within an undisturbed Precambrian Shield lake ecosystem was made. Concn of 21 naturally occurring elements including phosphorus were measured in sediments, clams, fish, birds, and mammals. Mercury was the only element to exhibit biomagnification. /Phosphorus/

... FEEDING RATS 3% & 5% ... SODIUM HEXAMETAPHOSPHATE RESULTED IN SEVERE KIDNEY DAMAGE, WHILE FEEDING 1.8% ... CAUSED NO OBSERVABLE PHYSIOLOGICAL DAMAGE. ... HOWEVER, WHEN DOGS WERE FED INCREASING DOSAGES ... BEGINNING AT 1.0 G/KG/DAY AND INCREASING TO 4.0 G/KG FOR THE LAST MONTH OF A 5-MONTH FEEDING PERIOD, THE DOGS ... BEGAN TO LOSE WEIGHT WHEN THE DAILY DOSE REACHED 2.5 G/KG/DAY.

SODIUM HEXAMETAPHOSPHATE DID NOT EXHIBIT GENETIC ACTIVITY IN THE FOLLOWING IN VITRO MICROBIAL ASSAYS: S TYPHIMURIUM (PLATE TESTS, NON-ACTIVATION SUSPENSION TESTS, ACTIVATION SUSPENSION TESTS); S CEREVISIAE (NON-ACTIVATION & ACTIVATION SUSPENSION TESTS).

ORAL ADMIN OF UP TO 240 MG/KG BODY WT TO PREGNANT RATS & UP TO 370 MG/KG BODY WT TO PREGNANT MICE (BOTH FOR 10 CONSECUTIVE DAYS) HAD NO DISCERNIBLE EFFECT ON NIDATION OR ON MATERNAL OR FETAL SURVIVAL. SOFT & SKELETAL TISSUE ABNORMALITIES SAME AS CONTROL.

Studies of animals showed that ... sodium hexametaphosphate fed at high concentrations in water /interferes/ ... with trace metal metabolism.

Sodium hexametaphosphate depressed the growth of 7 strains of Streptococcus mutans (serotype a-g) as assessed by disk diffusion methods. Minimal inhibitory concn of condensed phosphates on growth of strain Kl-R (g) in a chemically defined medium were measured turbidimetrically. The minimal inhibitory concn of condensed phosphates on Streptococcus mutans appeared to be related to their chelating capacity. As the growth inhibition by condensed phosphates was reversed by the addition of divalent metal ions (calcium(2+), magnesium(2+), manganese(2+)), the chelating capacity of condensed phosphates was apparently responsible for their antibacterial action.

1

PPRTV Current

4

PPRTV Current

LD50 Rat oral 6200 mg/kg

LD50 Mouse oral 4320 mg/kg

LD50 Mouse ip 870 mg/kg

LD50 Mouse sc 1300 mg/kg

LD50 Mouse iv 62 mg/kg

7.80e+04

1.20e+06

2.00e+04

1.5E+01(G)

1.00e+00

Volatile

2.30e+05

3.50e+06

6.00e+04

1.5E+01 (G)

1.00e+00

Volatile

Sodium hexametaphosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.

Sodium hexametaphosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Residues of sodium hexametaphosphate are exempted from the requirement of a tolerance when used as a surfactant, emulsifier, wetting agent, suspending agent, dispersing agent or buffer in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

... THIS SALT APPEARS TO BE HYDROLYZED WITHIN THE BOWEL TO PHOSPHORIC ACID ... .

In the body, phosphorus is converted to phosphates. /Phosphorus/

CIR ingredient: Sodium Hexametaphosphate

Used in building and water treatment (60%), food processing (15%), and miscellaneous (25%); Used in photographic developing, in dairy substitutes in pudding, as a retarder in dental alginate impression materials, and as a thinner for petroleum drilling fluids; [HSDB] At low concentrations, it inhibits steel corrosion and the formation of scale-forming compounds (calcium carbonate and calcium sulfate); [Hawley]

Petroleum Production and Refining [Category: Industry]

Improves efficiency of the developing process in photographic work.

Used as a dairy substitute in milk-based pudding.

Dentistry: Retarder in alginate impression materials.

Sodium hexametaphosphate detergents, calgon, giltex, quadrafos, hagan phosphate, micromet: mixtures containing Graham's salt as principal agent. Supplied in form of powder, flakes, & small, broken, glass-like particles.

... SEVERAL SODIUM HEXAMETAPHOSPHATE PREPN LABELED "REAGENT GRADE"... ARE TYPICAL COMMERCIAL MIXTURES OF VARYING CHAIN LENGTHS ... IT IS, THEREFORE, INCORRECT TO DESIGNATE THEM AS CHEMICALLY PURE OR REAGENT-GRADE ... .

Has molecular ratio of 1.1 Na2O:1 P2O5 with guaranteed min of 67% P2O5. Several specialized compositions are available. /Calgon/

/Vitreous sodium phosphate (sodium hexametaphosphate) found in/ Calgon; Calgon Bath Oil Beads; Calgon Bouquet; and Calgon Bubble Bath.

Food Additives -> EMULSIFIER; SEQUESTRANT; TEXTURIZER; THICKENER -> JECFA Functional Classes

Cosmetics -> Chelating

/Micromet is/ trademark for specially formulated phosphate glass ... used to inhibit scale, corrosion, & red water in water systems & air conditioning systems.

... /In water treatment/ sodium hexametaphosphate ... could continue to be used with care at dosage rates in water resulting in concentrations not to exceed that required to complex manganese by more than 10%, that is, no more than 1 mg/l.

While sometimes called "sodium hexametaphosphate," this substance is a mixture of polymeric metaphosphates; not a hexamer. /Glassy sodium metaphosphate; Graham's salt/

Molecular formula is (NaPO3)n where n is between about 6 and 20.

Calgon is a trademark for a sodium phosphate glass cleaner commonly called sodium hexametaphosphate.