Water → Tamsulosin

HRID 1063516

반응식

HRID 1063516 반응식
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15].Cl.[OH-].[Na+].O>CO>[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 5362376Tamsulosin Hydrochloride

생성물 1

HCID 129211Tamsulosin

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The crystals obtained in step d) were suspended in methanol (1 100 ml), the mixture was heated to reflux and sodium hydroxide solution (2M, 440 ml) was gradually added followed by water (350 ml). The mixture was cooled down to 10–15° C. Formed crystals were filtered and washed on filter with methanol (150 ml) and water (150 ml) mixture. Crystals were dried at 50° C. to give 340 g of product.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux
  3. temperatureThe mixture was cooled down to 10–15° C
  4. customFormed crystals
  5. filtrationwere filtered
  6. washwashed
  7. filtrationon filter with methanol (150 ml) and water (150 ml) mixture
  8. customCrystals were dried at 50° C.

출처 및 근거

ORD 기록
ord-ea18e88a065b45fbb2f15def55bbb14e
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06965051B2

연결된 노트

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