Hydrochloric Acid → 2-Ethoxy-4-aminobenzoic acid

HRID 1352657

반응식

HRID 1352657 반응식
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH:14]C(=O)C)[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7])[CH3:2].Cl>[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7])[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 6034Ethopabate

생성물 1

HCID 101763852-Ethoxy-4-aminobenzoic acid수율 100.2%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A suspension of methyl 2-ethoxy-4-acetamidobenzoate (50 g, 211 mmol) in aqueous solution of NaOH (15% W/W, 200 ml) was gently refluxed for 16 hours. The resulting pale brown solution was allowed to cool to room temperature and then further cooled in an ice water bath. Concentrated HCl (37% w/w) was added until the solution reached a pH of 6. The solid precipitated from the solution was filtered under vacuum, dried at 50° C. to give 38.3 g of the title compound (yield 100%).

후처리

  1. temperaturewas gently refluxed for 16 hours
  2. temperaturefurther cooled in an ice water bath
  3. customThe solid precipitated from the solution
  4. filtrationwas filtered under vacuum
  5. customdried at 50° C.

출처 및 근거

ORD 기록
ord-f89630faf6d341dabf6823615714d1c1
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220769B2

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