CAS 2832-19-1 N-Methylol-alpha-chloroacetamide (HCID 62466)

개요

2-chloro-N-(hydroxymethyl)acetamide is a member of acetamides.

이름 및 식별자

우선 이름: N-Methylol-alpha-chloroacetamide
IUPAC: 2-chloro-N-(hydroxymethyl)acetamide
현지명: 2-클로로-N-(히드록시메틸)아세트아미드
영어명: N-Methylolchloroacetamide
분자식: C3H6ClNO2
분자량: 123.54

이름 및 동의어

2-Chloro-N-(hydroxymethyl)acetamide2832-19-1GrotaACETAMIDE, 2-CHLORO-N-(HYDROXYMETHYL)-N-Methylol-chloracetamideDTXSID204141220J873AX6GChloractamide-N-methololDTXCID0021412RefChem:575562n-methylol-alpha-chloroacetamide220-598-9

이름 더 보기

2-클로로-N-(하이드록시메틸)아세트아마이드2-클로로-N-(히드록시메틸)아세트아미드N-Methylol-α-chloroacetamideGrotan HDTIMTEC-BB SBB004273N-Methylolchloroacetoro-N-(hydroxymethyLMETHYLOLCHLOROACETAMIDE

N-Hydroxymethyl-2-chloroacetamideN-MethylolchloroacetamideChloracetamide-N-methanolChloracetamide-N-methololMFCD00021961NSC-9963N-hydroxymethylchloroacetamideGrotan DF-35

데이터베이스 식별자

CAS: 2832-19-1
PubChem CID: 62466
DTXSID: DTXSID2041412
ChEMBL: CHEMBL3184823
ChEBI: CHEBI:232412
UNII: 20J873AX6G
EC Number: 220-598-9
Nikkaji: J7.919G

물성

구조 계산 물성

XLogP: -0.4
극성 표면적: 49.3 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 2
회전 가능 결합 수: 2
무거운 원자 수: 7
형식 전하: 0
복잡도: 66

실험 및 물리화학적 성질

Chemical ClassesOther Uses -> Biocides/Disinfectants

물리화학적 성질

녹는점: 100 · 100-105 °C(lit.)
끓는 점: 374 · 374.0±27.0 °C(Predicted)
밀도: 1.2776 · 1.2776 (rough estimate)
굴절률: 1.5 · 1.5000 (estimate)
저장 조건: 2 · Inert atmosphere,2-8°C
용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa): 12.63 · 12.63±0.46(Predicted)
물리적 상태: 고체
색상: 흰색에서 황백색까지
수용성: 물에 매우 잘 녹습니다. 지방족 탄화수소에는 잘 녹지 않습니다.
BRN: 1811765 · 1811765
InChI: InChI=1S/C3H6ClNO2/c4-1-3(7)5-2-6/h6H,1-2H2,(H,5,7)
InChIKey: TXNSZCSYBXHETP-UHFFFAOYSA-N
SMILES: C(NCO)(=O)CCl
EPA: 2 · 2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1)

화학적 성질

White or almost white crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 20% (12 of 60) of reports.

Danger

H314 (75%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P272, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 60 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Chemical: Acetamide, 2-chloro-N-(hydroxymethyl)-

Acetamide, 2-chloro-N-(hydroxymethyl)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards Summary · 1건

A formaldehyde releaser, N-methylolchloroacetamide can cause allergic contact dermatitis in workers; It thus appears that most formaldehyde-releasers in MWF cannot be considered frequent and important contact allergens. [Kanerva, p. 407] Danger of skin sensitization; [MAK] Sensitizer in coolant oils & cosmetics; [ChemIDplus]

Hazard Classes and CategoriesSkin Corr. 1A (75%)

독성 정보

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: AB5733000
ridadr: UN 3261 8/PG 2
HS 번호: 29241990
risk_code: 34-43-40-20/21/22
hazard_code: C
safety_code: 26-27-36/37/39-45
포장분류: Ⅱ
위험 등급: 8
기존화학 물질: KE-05702
Hazard Classifications: Eye Dam. 1Skin Corr. 1B
스토리지 클래스: 8A - Combustible corrosive hazardous materials

화학 및 산업

용도 및 제조

Uses · 2건

Used as a preservative in glues, metalworking fluids (MWF), and spin-finishes applied to nylon; [Kanerva, p. 406]

Metal Machining [Category: Heat or Machine]

General Manufacturing InformationAcetamide, 2-chloro-N-(hydroxymethyl)-: ACTIVE

응용 분야 · 2건

용도N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics.

일반 설명2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.