N-Methylol-alpha-chloroacetamide → 2-Chloro-N-[5-(1,1-dimethylethyl)-3-dimethylaminomethyleneaminosulfonyl-2-hydroxybenzyl]-acetamide

HRID 35397

반응식

HRID 35397 반응식
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([S:12]([N:15]=[CH:16][N:17]([CH3:19])[CH3:18])(=[O:14])=[O:13])[CH:6]=1)([CH3:4])[CH3:3].[Cl:20][CH2:21][C:22]([NH:24][CH2:25]O)=[O:23]>S(=O)(=O)(O)O>[Cl:20][CH2:21][C:22]([NH:24][CH2:25][C:9]1[CH:10]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[CH:6]=[C:7]([S:12]([N:15]=[CH:16][N:17]([CH3:19])[CH3:18])(=[O:13])=[O:14])[C:8]=1[OH:11])=[O:23]

참가 물질

4

반응물 2

HCID 62466N-Methylol-alpha-chloroacetamideHCID 541555634-(1,1-Dimethylethyl)-2-dimethylaminomethyleneaminosulfonylphenol

생성물 1

HCID 539481172-Chloro-N-[5-(1,1-dimethylethyl)-3-dimethylaminomethyleneaminosulfonyl-2-hydroxybenzyl]-acetamide

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

3 g (0.01 mole) of 4-(1,1-dimethylethyl)-2-dimethylaminomethyleneaminosulfonylphenol are dissolved in 30 ml of sulfuric acid, and 1.1 g (0.009 mole) of 2-chloro-N-hydroxymethylacetamide are added. The mixture is stirred for 30 minutes at room temperature and poured into ice water. The product is filtered off with suction and recrystallized from methanol.

후처리

  1. filtrationThe product is filtered off with suction
  2. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-aef4cd9e4021414984007a97f385e38f
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766241

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