Sulfuric Acid → 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

HRID 35412노트

반응식

HRID 35412 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH2:6][CH2:5]2.[Cl:11][CH2:12][C:13]([NH:15][CH2:16]O)=[O:14].S(=O)(=O)(O)O>C(O)(=O)C>[Cl:11][CH2:12][C:13]([NH:15][CH2:16][C:10]1[CH:9]=[C:8]2[C:4]([CH2:5][CH2:6][CH2:7]2)=[CH:3][C:2]=1[OH:1])=[O:14]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 151185-IndanolHCID 62466N-Methylol-alpha-chloroacetamide

생성물 1

HCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

134 g (1 mole) of 5-hydroxyindane and 100 g (0.81 mole) of 2-chloro-N-hydroxymethylacetamide are suspended in 300 ml of glacial acetic acid, and 10 ml of concentrated sulfuric acid are added. The mixture is stirred for 30 minutes at room temperature and is poured into ice water. The product is filtered off with suction and recrystallized from methanol.

후처리

  1. filtrationThe product is filtered off with suction
  2. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-9f24ddb28e444a7a9f35cd26d6f49873
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766241

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