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1.20 at 105 °C

1.4 g/cm³

1.2 @ 105°C

Slightly soluble in petroleum ether and ethyl ether; soluble in benzene

Solubility in water, g/l at 20 °C: 29.4 (reaction)

315 °F (157 °C) Open cup

157 °C o.c.

Crystals from petroleum ether. MP: 103.5 °C. Soluble in ethanol, acetone, chloroform, benzene; slightly soluble in petroleum ether. /cis-1,2,3,6-Tetrahydrophthalic anhydride/

102 °C

0.05 [mmHg]

Vapor pressure, Pa at 20 °C: 1

0.057 [mm Hg] @25 °C

Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P264+P265, P271, P272, P273, P280, P284, P302+P352, P304+P340, P305+P354+P338, P317, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Danger

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P264+P265, P271, P272, P273, P280, P284, P302+P352, P304+P340, P305+P354+P338, P317, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Chemical: 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-

Chemical: 1,3-Isobenzofurandione, tetrahydro-

Hazard Traits - Respiratory Toxicity

Hazard Traits - Respiratory Toxicity

1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 10-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14373

IMAP assessments - Tetrahydrophthalic anhydrides and analogues: Human health tier II assessment

IMAP assessments - Tetrahydrophthalic anhydrides and analogues: Human health tier II assessment

Corrosive

Corrosive

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

· Combustible material: may burn but does not ignite readily.

Combustible. Finely dispersed particles form explosive mixtures in air.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

· TOXIC and/or CORROSIVE; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death.

Decomposed by hot surfaces or flames forming corrosive vapors; Reacts with water evolving heat and tetrahydrophthalic acid; A skin, eye, and respiratory tract irritant; May cause skin sensitization and asthma after prolonged contact; [ICSC] Corrosive to skin, eye, and respiratory tract; [HSDB] Reacts exothermically with water producing tetrahydrophthalic acid; A strong skin, eye, and mucous membrane irritant; Corrosive to skin; [CAMEO] May be irritating or corrosive to eyes, based on animal studies; [CHEMINFO] Corrosive to eyes; May cause skin and respiratory sensitization after prolonged contact; [eChemPortal: ERMA; ESIS] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; [MSDSonline]

Hydrocarbons, Aliphatic Unsaturated

Hydrocarbons, Aliphatic Unsaturated

European Chemicals Bureau; IUCLID Dataset, 1,2,3,6-Tetrahydrophthalic anhydride (CAS No. 85-43-8) (2000 CD-ROM edition). Describes information on usage patterns, toxicity, and ecoogical effects provided by industry to the European Union. Available from the database query page: http://ecb.jrc.it/esis/esis.php as of August 29, 2006.

Water-Reactive

Water-Reactive

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

Use water spray, powder, foam, carbon dioxide.

Fresh air, rest. Refer for medical attention.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

General First Aid:

The substance can be absorbed into the body by inhalation of its aerosol. Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

The substance decomposes on contact with hot surfaces or flames producing corrosive fumes.

EC50 Scenedesmus subspicatus (algae) 65.7 mg/L/72 hr; Effect: growth rate /Conditions of bioassay not specified in source examined/

LC50 Leuciscus idus (orfe) 610 mg/L/48 hr; static

LC50; Species: Bufo bufo japonicus (Toad); Conditions: freshwater; static; Concentration: > 40000 ug/L for 24 hr at 25 °C, pH 5.0 °C /formulated product/

LC50; Species: Bufo bufo japonicus (Toad); Conditions: freshwater; static; Concentration: > 40000 ug/L for 24 hr at 25 °C, pH 6.0 °C /formulated product/

For more Ecotoxicity Values (Complete) data for TETRAHYDROPHTHALIC ANHYDRIDE (8 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on the structural similarities to phthalic anhydride, tetrahydrophthalic anhydride is expected to have a similar hydrolysis rate(SRC). Phthalic anhydride has been reported to hydrolyze rapidly in water(1) and estimated half-lives of approximately 1.5 minutes and 2.7 minutes were calculated(SRC) using reported observed rate constants of 7.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively. Based upon this hydrolysis rate, tetrahydrophthalic anhydride is expected to hydrolyze in moist soils(SRC). Volatilization from soil surfaces and adsorption to soil are not expected to be important processes because of hydrolysis(SRC). Biodegradation data were not available(SRC, 2006).

AQUATIC FATE: Based on the structural similarities to phthalic anhydride, tetrahydrophthalic anhydride is expected to have a similar hydrolysis rate(SRC). Phthalic anhydride has been reported to hydrolyze rapidly in water(1) and estimated half-lives of approximately 1.5 minutes and 2.7 minutes were calculated(SRC) using reported observed rate constants of 7.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively. Therefore, volatilization from water surfaces, adsorption to suspended solids and sediments, biodegradation, and bioconcentration are not expected to be important in aquatic systems based on hydrolysis(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetrahydrophthalic anhydride, which has an estimated vapor pressure of 5.75X10-2 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetrahydrophthalic anhydride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.4 hours(SRC), calculated from its rate constant of 6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The rate constant for the vapor-phase reaction of tetrahydrophthalic anhydride with ozone has been estimated as 2X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). This corresponds to an atmospheric half-life of about 1.4 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(4).

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Tetrahydrophthalic anhydride is produced, as an intermediate or a final product, by process units covered under this subpart.

... 3-hydroxycyclohexane-1,2-carboximide (OHHPI-1/2)2 and and 1-hydroxy-1,2-cyclohexanedicarboxylic-acid (OHHPA) were detected in urine and feces samples from noncannulated rats and in bile and urine samples from cannulated rats. 1,2-cyclohexanedicarboxylic-acid (TCDA) was detected only in urine and feces samples from noncannulated rats administered 3,4,5,6-tetrahydrophthalimide (TPI) orally. Following 3,4,5,6-tetrahydrophthalic-acid (THPA) administration, OHHPA was detected in all excreta except in feces from bile duct cannulated rats injected intravenously. TCDA was detected in feces samples from noncannulated rats administered THPA intravenously and in all excreta from bile duct cannulated rats administered THPA orally. No OHHPA was detected in rats administered TCDA. Liver, stomach, intestinal tissues plus contents, and kidneys, lung, spleen, and pancreas, plasma and blood cell samples obtained from untreated male Sprague-Dawley-rats were incubated with 40 nanomoles C14 labeled TPI or THPA for 1 hour. The mixtures were analyzed for metabolites as before. cis-1,2-Cyclohexanedicarboximide was detected in supernatants from blood cells following incubation with TPI. THPA and 3,4,5,6-tetrahydrophthalic-anhydride (TPA) were detected in the plasma and other tissues. Following incubation with THPA, trans-TCDA was detected in the intestinal tissues, OHHPA was detected in the intestine and liver, and TPA was detected in the other tissues, blood cells, and plasma.

Used as an intermediate for light-colored alkyds, polyesters, plasticizers, adhesives, and pesticides; Also used as a hardener for resins, an anti-scorching agent in the rubber industry, and to make paints, lacquers, and varnishes; [HSDB]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

Paints, lacquers and varnishes industry ... polymer industry ...

Chemical intermediate for light-colored alkyds, polyesters, plasticizers & adhesives; intermediate for pesticides; hardener for resins.

Used as anti-scorching agent in the rubber industry.

2023: 10,000,000 - <25,000,000 lb

This chemical is listed as a High Production Volume (HPV) (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#2280]

Utilities

1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-: ACTIVE

1,3-Isobenzofurandione, tetrahydro-: ACTIVE