Hydrochloric Acid → N-methyl-N'-[2-((2-amino-4-imidazolyl)methylthio)ethyl]thiourea

HRID 26830

반응식

Cl.NC1NC=C(CO)N=1.C1(C([O-])=C([N+]([O-])=O)C=C([N+]([O-])=O)C=1)[N+]([O-])=O.Cl.Cl.NCCS.[NH2:32][C:33]1[NH:34][CH:35]=[C:36]([CH2:38][S:39][CH2:40][CH2:41][NH2:42])[N:37]=1.[CH3:43][N:44]=[C:45]=[S:46]>>[CH3:43][NH:44][C:45]([NH:42][CH2:41][CH2:40][S:39][CH2:38][C:36]1[N:37]=[C:33]([NH2:32])[NH:34][CH:35]=1)=[S:46]

참가 물질

반응물 6

HCID 313Hydrochloric Acid

HCID 9082Cysteamine Hydrochloride

HCID 11167Methyl isothiocyanate

HCID 4432340Picrate

HCID 178479151HCID 178479151, 화합물

HCID 178511470HCID 178511470, 화합물

생성물 1

HCID 178486118N-methyl-N'-[2-((2-amino-4-imidazolyl)methylthio)ethyl]thiourea

실험 절차

Reaction of 2-amino-4-hydroxymethylimidazole hydrochloride (which is obtained by treating the picrate salt with hydrochloric acid) with cysteamine hydrochloride and reaction of the resulting 2-amino-4-[(2-aminoethyl)thiomethyl]imidazole with methyl isothiocyanate by the methods of Example 1 gives N-methyl-N'-[2-((2-amino-4-imidazolyl)methylthio)ethyl]thiourea.

후처리

customis obtained

출처 및 근거

ORD 기록: ord-a98ca8b2a24d4862b7388c20e6e70c8f
출처 데이터셋: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04151288

연결된 노트

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