겐타미신 황산염

Gentamicin Sulfate

HCID 9855350

기본 정보

CAS
1405-41-0
표준 SMILES
CNC(C)[C@@H]1CC[C@@H](N)[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)O1.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](C(C)N)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O.O=S(=O)(O)O
InChIKey
RDEIXVOBVLKYNT-VQBXQJRRSA-N
분자식
C60H125N15O25S
평균 분자량
1,488.8 g/mol
단동위원소 질량
1,487.86917571

이름 및 식별자

우선 이름
Gentamicin Sulfate
IUPAC
(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
현지명
겐타미신 황산염
영어명
Gentamicin sulfate
분자식
C60H127N15O26S
분자량
1506.8

이름 및 동의어

GentakGENTAMICIN SULPHATEGentacidinGentibioptalBristagenGaracinGenopticGentacinGentafairGentalynGenticinGentogram
이름 더 보기
겐타미신황산염겐타미신황산염(GENTAMYCINSULFATE)Gentamycin sulfateGENTAMICIN SULPHATE STERILE100ppmU-gencinGENTAMICIN 2,5-SULFATE HYDRATEsch9724
OphtagramPangramSeptopalApogenGentaMedGarasol SolutionGent-OphtalDTXSID0037235

데이터베이스 식별자

CAS
1405-41-0
PubChem CID
9855350
EC Number
215-778-9

물성

구조 계산 물성

극성 표면적
710 Ų
수소 결합 공여자 수
26
수소 결합 수용자 수
40
회전 가능 결합 수
19
무거운 원자 수
101

실험 및 물리화학적 성질

SolubilitySoluble (NTP, 1992)
Melting Point424 to 459 °F (NTP, 1992)
Physical DescriptionSulfate salt of an antibiotic complex produced by fermentation. Three closely related components that are chemically amino-saccharides. White to buff-colored powder. pH (4% solution) 3.5 to 5.5. Odorless. (NTP, 1992)

물리화학적 성질

녹는점
218 · 218-237°C
밀도
1 g/cm3 · 1.000 g/cm3
저장 조건
2 · 2-8°C
용해도
2 O: · H2O: 50 mg/mL 원액으로 '20°C에 보관하세요. 37°C에서 5일 동안 안정합니다.
물리적 상태
가루
색상
무색~연황색
화학적 성질 · 1건

White to buff-colored powder, hygroscopic, easily soluble in water, insoluble in lipids, insoluble in organic solvents, stable in chemical properties, relatively stable to changes in temperature and pH, the pH of 4% aqueous solution is 4.0-6.0. There are five basic centers in the gentamicin molecule, which is a basic compound, and the drug is the sulfate of gentamicin. Gentamicin is a complex of C components, the main components of which are C1, C2, C1a, and C2a.

안전 및 규제

GHS 분류

GHS Classification · 5건

Danger

H317 (98.5%): May cause an allergic skin reaction [Warning Sensitization, Skin];H334 (69.2%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory];H335 (28.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H361 (11.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 412 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory InformationGentamycin sulphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Gentamicin, sulfate (salt): Environment tier I assessment;IMAP assessments - Gentamicin, sulfate (salt): Human health tier I assessment
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards · 1건

SYMPTOMS: Symptoms of exposure to this compound include vestibular damage, ototoxicity, hypersensitivity reactions, anemia, purpura, convulsions, increased serum aminotransferase values, increased serum-bilirubin concentrations, alopecia, blood disorders, electrolyte disturbances, nephrotoxicity, neuromuscular blockade, neurotoxicity and psychosis. Other symptoms include vertigo, tinnitus, hearing loss, allergic reactions and fever. Numbness, skin tingling, muscle twitching and roaring in the ears has also been reported. Topical application has resulted in redness and itching of the skin. This compound is poorly absorbed from the gastrointestinal tract, but is rapidly absorbed after intramuscular injection.;ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of SOx. (NTP, 1992)

Reactive GroupSalts, Acidic;Acetals, Ketals, Hemiacetals, and Hemiketals
Reactivity ProfileGENTAMYCIN SULFATE is very stable in solution, even in moderately acidic to strongly basic aqueous media. (NTP, 1992)

안전 및 보호

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1건

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992)

Personal Protective Equipment (PPE) · 1건

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

규제 정보

Regulatory InformationGentamycin sulphate: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk
2
rtecs
LY2625000
독성
LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black)
HS 번호
29419010
risk_code
42/43
hazard_code
Xn

화학 및 산업

약리 정보

FDA Pharmacological Classification · 4건

GENTAMICIN SULFATE

Aminoglycoside Antibacterial [EPC]; Aminoglycosides [CS]

GENTAMICIN SULFATE OPTH SOLUTION

Aminoglycoside Antibacterial [EPC]; Aminoglycosides [CS]

MeSH Pharmacological Classification · 2건

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

Substances that inhibit the growth or reproduction of BACTERIA.

용도 및 제조

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
응용 분야 · 2건

용도Gentamicin sulfate is an aminoglycoside antibiotic. Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial. Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the complex but is similar to Kanamycin C. Gentamicin C1: R1=R2=CH3 Gentamicin C2: R1=CH3; R2=H Gentamicin C1A: R1=R2=H.

일반 설명Gentamicin sulfate is a sulfate salt of an antibiotic complex produced by fermentation of Micromonospora purpurea or M. echinospora. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base. Three closely related components that are chemically amino-saccharides. White to buff-colored powder. pH (4% solution) 3.5 to 5.5. Odorless.

공급사100 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

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