Calcium Sulfate Dihydrate → Ibuprofen, (+-)-

HRID 1392996

반응식

HRID 1392996 반응식
O.O.S([O-])([O-])(=O)=O.[Ca+2].CC(N)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.CC(NC)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.C[C@@]1(O)[C@H](NC)[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC1.OS(O)(=O)=O.[Na+].[O-:111][C:112]([CH:114]([C:116]1[CH:125]=[CH:124][C:119]([CH2:120][CH:121]([CH3:123])[CH3:122])=[CH:118][CH:117]=1)[CH3:115])=[O:113]>>[OH:113][C:112]([CH:114]([C:116]1[CH:117]=[CH:118][C:119]([CH2:120][CH:121]([CH3:122])[CH3:123])=[CH:124][CH:125]=1)[CH3:115])=[O:111]

참가 물질

4

반응물 3

HCID 24928Calcium Sulfate DihydrateHCID 5338317Ibuprofen, Sodium SaltHCID 9855350Gentamicin Sulfate

생성물 1

HCID 3672Ibuprofen, (+-)-

실험 절차

A mixture of 1,000.0 mg calcium sulfate dihydrate (Fluka), 250.0 mg poly-L-lactide (M-10,000 g/mol), 49.7 mg gentamicin sulfate (AK 628) and 78.5 mg ibuprofen sodium salt (produced through the neutralization of ibuprofen (Fluka)) is ground up. 200 mg of this mixture, respectively, are pressed with a press at a pressure of 5 tons within a period of two minutes into disk-shaped molded bodies with a diameter of 13 mm.

출처 및 근거

ORD 기록
ord-3d66397312594603a9d6836f64207d8f
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07345024B2

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