p-Xylyl bromide → S-p-Methylbenzyl-L-cysteine

HRID 1003649노트

반응식

HRID 1003649 반응식
O.Cl.[NH2:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][SH:6].Br[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1>[OH-].[Na+].C(O)C>[CH3:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][S:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[NH2:3])=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 7721p-Xylyl bromideHCID 23462L-Cysteine hydrochloride monohydrate

생성물 1

HCID 13994756S-p-Methylbenzyl-L-cysteine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

L-Cysteine hydrochloride monohydrate (2.0 g) is dissolved in a 2 N aqueous sodium hydroxide solution (11.4 ml). To the solution is added a solution of α-bromo-p-xylene (2.3 g) in ethanol (10 ml). The mixture is stirred at room temperature for 40 minutes, and precipitating crystals are filtered off. The obtained crystals are purified by recrystallization to give the titled compound.

후처리

  1. customprecipitating crystals
  2. filtrationare filtered off
  3. customThe obtained crystals are purified by recrystallization

출처 및 근거

ORD 기록
ord-2bd0214789884754b1d748c3c1b81b2a
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046235

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