Water → 5-(Bromomethyl)benzo[d]oxazole

HRID 1004323노트

반응식

HRID 1004323 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[N:7][C:6]=2[CH:10]=1.[Br:11]N1C(=O)CCC1=O.O>C(Cl)(Cl)Cl>[Br:11][CH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[N:7][C:6]=2[CH:10]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 27249705-Methylbenzoxazole

생성물 1

HCID 219849815-(Bromomethyl)benzo[d]oxazole

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 5-methylbenzoxazole (0.5 g) in chloroform (20 ml) containing N-bromosuccinimide (0.18 g) and azoisobutyronitrile (0.05 g) was refluxed for 2 hours. After allowing to cool to room temperature the reaction mixture was treated with water (30 ml). The organic phase was separated and the aqueous phase extracted with dichloromethane (30 ml). The combined organic phases were washed with brine (30 ml), dried over magnesium sulphate and evaporated. The residue was triturated with pentane giving the title compound (0.36 g) as an off-white solid, m.p. 90-93° C.

후처리

  1. temperaturewas refluxed for 2 hours
  2. customThe organic phase was separated
  3. extractionthe aqueous phase extracted with dichloromethane (30 ml)
  4. washThe combined organic phases were washed with brine (30 ml)
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. customThe residue was triturated with pentane giving the title compound (0.36 g) as an off-white solid, m.p. 90-93° C.

출처 및 근거

ORD 기록
ord-42fa2a3da2d14b809218e78819ccab3c
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06048893

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