Hydrochloric Acid → 2-[4-(Dimethylamino)phenyl]-2-methylpropanoic acid

HRID 1005427노트

반응식

HRID 1005427 반응식
[CH3:1][N:2]([CH3:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH3:16])([CH3:15])[C:10]([O:12]CC)=[O:11])=[CH:5][CH:4]=1.[OH-].[Na+].Cl>C(O)C.O>[CH3:17][N:2]([CH3:1])[C:3]1[CH:4]=[CH:5][C:6]([C:9]([CH3:15])([CH3:16])[C:10]([OH:12])=[O:11])=[CH:7][CH:8]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57182128HCID 57182128, 화합물

생성물 1

HCID 206960032-[4-(Dimethylamino)phenyl]-2-methylpropanoic acid수율 92%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of ethyl (4-dimethylaminophenyl)-2,2-dimethylacetate (1.00 g, 4.25 mmol) and sodium hydroxide (0.85 g) in ethanol (20 ml ) and water (9 mL) was heated under reflux for 18 hours. The mixture was cooled, acidified with 10% HCl, and washed with ethyl acetate. The aqueous phase was evaporated. The residue was dissolved in aqueous saturated sodium bicarbonate, and extracted with ethyl acetate. The organic phase was dried, filtered and evaporated to give (4-dimethylaminophenyl)-2,2-dimethylacetic acid as a faint red solid (0.81 g, 92%).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. temperatureThe mixture was cooled
  4. washwashed with ethyl acetate
  5. customThe aqueous phase was evaporated
  6. dissolutionThe residue was dissolved in aqueous saturated sodium bicarbonate
  7. extractionextracted with ethyl acetate
  8. customThe organic phase was dried
  9. filtrationfiltered
  10. customevaporated

출처 및 근거

ORD 기록
ord-ae6e576aba264cbd81bac924c02d5987
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06054470

반응 노트

불러오는 중…