Water → 2-(2-Bromo-3-methylphenyl)ethylmethylether
반응식
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][OH:11].[H-].[Na+].[CH3:14]I.O>O1CCCC1.C(O)(=O)C>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][O:11][CH3:14]참가 물질
7
실험 절차
To a stirred solution of 2-(2-bromo-3-methylphenyl)ethanol (1.6 g, 7.4 mmol) in tetrahydrofuran (20 ml) was added sodium hydride (50% in oil) (0.46 g, 9.6 mmol). After stirring the mixture for 15 min methyl iodide (1.6 g, 11.3 mmol) was added and the reaction mixture was stirred for 3 h. at room temperature. Water (0.2 g) was added and then acetic acid (0.2 g). The solvents were evaporated under reduced pressure and purification of the residue by column chromatography on silica gel using methylene chloride as eluent gave 1.5 g (89%) of the desired product as an oil.
후처리
- additionwas added
- customThe solvents were evaporated under reduced pressure and purification of the residue by column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-1b1428be00a1446b8e33c33e8efbd0fa
- 출처 데이터셋
- uspto-grants-2004_09
- 특허 번호
- US06790960B2
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