4-Hydroxy-3-methoxybenzonitrile → 3,4-Dihydroxybenzonitrile

HRID 1006705

반응식

C([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12]CC)[C:7]#[N:8])C.COC1C=C(C=CC=1O)C#N.[Br-].[Li+]>>[OH:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[OH:12])[C:7]#[N:8]

참가 물질

반응물 3

HCID 781354-Hydroxy-3-methoxybenzonitrile

HCID 82050Lithium Bromide

HCID 129461903,4-Diethoxybenzonitrile

생성물 1

HCID 870653,4-Dihydroxybenzonitrile수율 79%

실험 절차

The preparation was carried out according to the process of Example 2a except that 3,4-diethoxybenzonitrile was used as the starting material instead of 3-methoxy-4-hydroxybenzonitrile, and 2-fold of lithium bromide (162.6 g, 1.88 mole) were added to form the reaction mixture. 3,4-Dihydroxybenzonitrile was obtained as a white solid with a yield of 79% and a purity of greater than 92% as indicated by HPLC analysis.

후처리

customto form the reaction mixture

출처 및 근거

ORD 기록: ord-59cb6a1788d04c77932ef7acef6dc074
출처 데이터셋: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06790977B2

연결된 노트

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