Nitric Acid → HCID 86588302, 화합물

HRID 1007076

반응식

HRID 1007076 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][S:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:3]=1.[N+:18]([O-:21])([OH:20])=[O:19]>CO.C(#N)C>[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:3]=1.[N+:18]([O-:21])([O-:20])=[O:19]

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 5329Sulfamethoxazole

생성물 1

HCID 86588302HCID 86588302, 화합물수율 60%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6342Acetonitrile용매

실험 절차

The compound is prepared by starting from a Sulfamethoxazole solution (2 g, 7.9 mmoli) in methanol (100 ml), addition of a 65% nitric acid solution (0.500 ml) in acetonitrile (5 ml), following the procedure reported in Example 5. Sulfamethoxazole nitrate as amorphous solid is obtained. Yield 60%.

후처리

  1. customThe compound is prepared

출처 및 근거

ORD 기록
ord-7e868392ac6d4e0dbe7cd7f6fb4e6bd2
출처 데이터셋
uspto-grants-2004_09
특허 번호
US06794372B2

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