Hydrochloric Acid → HCID 25111160, 화합물

HRID 1009746노트

반응식

HRID 1009746 반응식
[CH2:1]([N:3]1[CH:7]=[C:6]([NH:8][C:9](=[O:34])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([O:32][CH3:33])=[C:25]([C:28]([O:30]C)=[O:29])[CH:26]=4)[N:21]=[CH:20][CH:19]=3)=[CH:13][CH:12]=2)[CH:5]=[N:4]1)[CH3:2].[OH-].[Li+].Cl>CO>[CH2:1]([N:3]1[CH:7]=[C:6]([NH:8][C:9](=[O:34])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([O:32][CH3:33])=[C:25]([C:28]([OH:30])=[O:29])[CH:26]=4)[N:21]=[CH:20][CH:19]=3)=[CH:13][CH:12]=2)[CH:5]=[N:4]1)[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 25112108N-(1-ethylpyrazol-4-yl)-2-[4-(7-methoxy-6-methoxycarbonylquinolin-4-yloxy)phenyl]acetamide

생성물 1

HCID 25111160HCID 25111160, 화합물수율 57.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of N-(1-ethylpyrazol-4-yl)-2-[4-(7-methoxy-6-methoxycarbonylquinolin-4-yloxy)phenyl]acetamide (0.05 g), lithium hydroxide (0.01 g) and methanol (1 ml) was stirred at ambient temperature for 14 hours. The resultant mixture was acidified to pH2 by the addition of 2N aqueous hydrochloric acid. The precipitate was isolated, washed with water and with diethyl ether and dried under vacuum. There was thus obtained the title compound (0.028 g); 1H NMR: (DMSOd6) 1.32 (t, 3H), 3.63 (s, 2H), 3.97 (s, 3H), 4.03-4.11 (m, 2H), 6.48 (d, 1H), 7.27 (d, 2H), 7.42 (s, 1H), 7.46 (d, 2H), 7.5 (s, 1H), 7.9 (s, 1H), 8.54 (s, 1H), 6.67 (d, 1H), 10.21 (s, 1H); Mass Spectrum: M+H+ 447.

후처리

  1. customThe precipitate was isolated
  2. washwashed with water and with diethyl ether
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-b7a84ee4b7454b7a86c402f4ee2c9ecb
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973164B2

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