Hydrochloric Acid → HCID 22936444, 화합물

HRID 1010364노트

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HRID 1010364 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:26]=[CH:25][C:7]([O:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([C:19]([O:21]C)=[O:20])[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:6][C:5]=1[N+:27]([O-:29])=[O:28].Cl>CO>[Cl:3][C:4]1[CH:26]=[CH:25][C:7]([O:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:6][C:5]=1[N+:27]([O-:29])=[O:28]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22936400HCID 22936400, 화합물

생성물 1

HCID 22936444HCID 22936444, 화합물수율 93.1%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
60 °C

실험 절차

After adding methanol (30 ml) and 2N aqueous sodium hydroxide (10 ml) to methyl 4-(4-chloro-3-nitrophenoxy)-7-methoxy-6-quinolinecarboxylate (1.00 g, 2.57 mmol), the mixture was stirred at 60° C. for 1 hour. The reaction solution was allowed to cool to room temperature, 2N hydrochloric acid was added for neutralization, the methanol was distilled off, and the precipitated light brown crystals were filtered out, thoroughly washed with water and dried at 70° C. to obtain the title compound (897 mg, 2.39 mmol, 93.1%).

후처리

  1. temperatureto cool to room temperature
  2. distillationthe methanol was distilled off
  3. filtrationthe precipitated light brown crystals were filtered out
  4. washthoroughly washed with water
  5. customdried at 70° C.

출처 및 근거

ORD 기록
ord-65cce2af7e684dae82f2d5394b2b895d
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07973160B2

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