Hydrochloric Acid → HCID 67021617, 화합물

HRID 1010717노트

반응식

HRID 1010717 반응식
C[O:2][C:3](=[O:20])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)=[CH:7][CH:6]=1.[Li+].[OH-].Cl>C1COCC1>[N:11]1([C:8]2[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:20])=[O:2])=[CH:6][CH:7]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=[CH:12]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67021552HCID 67021552, 화합물

생성물 1

HCID 67021617HCID 67021617, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
45 °C

실험 절차

A mixture of 0.535 g of (4-benzoimidazol-1-yl-phenyl)-acetic acid methyl ester and 2 ml of an 1N aqueous solution of LiOH in 2 ml of THF is stirred for 3 hours at 45° C. The mixture obtained is allowed to cool to rt and acidified to pH 5 by addition of 0.5 N aqueous HCl. A solid precipitates and is collected by vacuum filtration. (4-Benzoimidazol-1-yl-phenyl)-acetic acid is obtained. ES-MS: 253.1 [M+H]+; single peak at tR=2.36 min (System 1).

후처리

  1. customThe mixture obtained
  2. temperatureto cool to rt
  3. customA solid precipitates
  4. filtrationis collected by vacuum filtration

출처 및 근거

ORD 기록
ord-2ed09974cb9c42cc8f54a11e708b18b8
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977338B2

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