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1-Methoxy-2-propanol → 2-{[1-Methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

HRID 1011004
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HRID 1011004 반응식
[K].[O-]CCCC.Cl[C:8]1[N:16]=[C:15]2[C:11]([N:12]=[CH:13][N:14]2[CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)=[C:10]([NH2:23])[N:9]=1.[CH3:24][O:25][CH2:26][CH:27]([OH:29])[CH3:28]>>[CH3:28][CH:27]([O:29][C:8]1[N:16]=[C:15]2[C:11]([N:12]=[CH:13][N:14]2[CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)=[C:10]([NH2:23])[N:9]=1)[CH2:26][O:25][CH3:24]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 79001-Methoxy-2-propanolHCID 5462222PotassiumHCID 12476378Butan-1-olateHCID 127778192-Chloro-9-(tetrahydropyran-2-yl)adenine

생성물 1

HCID 576996342-{[1-Methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine수율 84.7%

반응 조건

온도
85 °C

실험 절차

To a stirred solution of potassium t.butoxide (9.3 g, 82.8 mmol) in 1-methoxy-2-propanol (70 ml) was added 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7 g, 27.6 mmol). The mixture was heated to 80-90° C. for 4 h. Then most of the solvent was removed by evaporation under reduced pressure. The residue was partitioned between water and dichloromethane. The dichloromethane layer was separated, concentrated to give a brown oil (7.2 g, 84.7%).

후처리

  1. customThen most of the solvent was removed by evaporation under reduced pressure
  2. customThe residue was partitioned between water and dichloromethane
  3. customThe dichloromethane layer was separated
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-547a010ad50648109fb63c2d1b1f8c4a
출처 데이터셋
uspto-grants-2011_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07977344B2

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