Hydrochloric Acid → HCID 25025366, 화합물

HRID 1011164

반응식

HRID 1011164 반응식
[CH3:1][CH:2]([CH3:25])[CH2:3][CH2:4][O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:22]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[C:8]([NH2:24])[N:7]=1.Cl.[OH-].[Na+]>CO.O1CCOCC1>[NH2:24][C:8]1[N:7]=[C:6]([O:5][CH2:4][CH2:3][CH:2]([CH3:25])[CH3:1])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:22])[N:12]2[CH2:15][CH:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 576997862-[(3-Methylbutyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-Purin-6-amine

생성물 1

HCID 25025366HCID 25025366, 화합물수율 62.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of 2-[(3-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (52 mg) in dry MeOH (5.7 mL) was added 4N HCl in 1,4-dioxane (0.971 mL) and the reaction mixture was stirred at room temperature for 3 h. The reaction was neutralised to pH7 with 2M sodium hydroxide solution and concentrated in vacuo to give a white solid. The solid was washed with water (20 mL) and was filtered under reduced pressure to give the title compound as an off-white solid (31 mg).

후처리

  1. concentrationconcentrated in vacuo
  2. customto give a white solid
  3. washThe solid was washed with water (20 mL)
  4. filtrationwas filtered under reduced pressure

출처 및 근거

ORD 기록
ord-65ef9de3cb044d3a9fea865cf66cb271
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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