Hydrochloric Acid → 6-Amino-2-(butyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-7,9-dihydro-8H-purin-8-one

HRID 1011206노트

반응식

HRID 1011206 반응식
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]2[CH2:22][CH2:21][O:20][CH2:19]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl.[OH-].[Na+]>CO.O1CCOCC1>[NH2:25][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]1[CH2:22][CH2:21][O:20][CH2:19]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 576996812-(Butyloxy)-8-(methyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-9H-purin-6-amine

생성물 1

HCID 576995966-Amino-2-(butyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-7,9-dihydro-8H-purin-8-one수율 70%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of 2-(butyloxy)-8-(methyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-9H-purin-6-amine (110 mg, 0.315 mmol) in methanol (9 ml) at room temperature was added 4M HCl in dioxane (1.89 ml). The pale yellow solution was stirred at room temperature for 18 hrs and then neutralised with 2M sodium hydroxide solution and evaporated to give a white solid. Trituration with water and filtration afforded the title compound as a cream solid (74 mg).

후처리

  1. customevaporated
  2. customto give a white solid
  3. filtrationTrituration with water and filtration

출처 및 근거

ORD 기록
ord-20cebc6e456c41ad8c16fb90837aa8a4
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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