tert-Butanol → HCID 23159792, 화합물

HRID 1011430노트

반응식

HRID 1011430 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6](C(O)=O)[CH:7]=[N:8]2.CC[N:18]([CH2:21]C)CC.N(P(=O)(OC1C=CC=CC=1)[O:27]C1C=CC=CC=1)=[N+]=[N-].[C:42]([OH:46])([CH3:45])([CH3:44])[CH3:43]>>[C:42]([O:46][C:21]([NH:18][C:6]1[CH:7]=[N:8][C:9]2[C:4]([CH:5]=1)=[C:3]([O:2][CH3:1])[CH:12]=[CH:11][CH:10]=2)=[O:27])([CH3:45])([CH3:44])[CH3:43]

참가 물질

5

반응물 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 123414Diphenylphosphoryl azideHCID 231597415-Methoxyquinoline-3-carboxylic acid

생성물 1

HCID 23159792HCID 23159792, 화합물

실험 절차

To a solution of 5-methoxy-3-quinolinecarboxylic acid (2 g, 10 mmol) prepared in stage A of example 9 in tert-BuOH (15 mL) was added NEt3 (1.2 g, 12 mmol) and diphenyl azidophosphonate (DPPA) (2.1 mL, 10 mmol). The reaction mixture is refluxed for 24 hours. The solvent is evaporated under vacuum and the residue is dissolved in AcOEt (50 mL) and washed with a saturated NaHCO3 solution. After drying, the solvent is evaporated under vacuum affording the title compound.

후처리

  1. temperatureThe reaction mixture is refluxed for 24 hours
  2. customThe solvent is evaporated under vacuum
  3. dissolutionthe residue is dissolved in AcOEt (50 mL)
  4. washwashed with a saturated NaHCO3 solution
  5. customAfter drying
  6. customthe solvent is evaporated under vacuum

출처 및 근거

ORD 기록
ord-508f4deec15345079de4055d83592843
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977354B2

반응 노트

불러오는 중…