Pyridine → HCID 18403464, 화합물

HRID 1017210노트

반응식

HRID 1017210 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([O:8][CH2:9][CH2:10][NH2:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].N1C=CC=CC=1.[C:20](Cl)(=[O:24])[CH:21]([CH3:23])[CH3:22]>C(Cl)Cl.Cl>[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([O:8][CH2:9][CH2:10][NH:11][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

6

반응물 3

HCID 1049PyridineHCID 62325Isobutyryl chlorideHCID 122944662-(4-Nitrophenoxy)ethanamine

생성물 1

HCID 18403464HCID 18403464, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 6344Dichloromethane용매

실험 절차

2-(4-Nitro-phenoxy)ethylamine (0.27 g) was dissolved in dry DCM (8.5 ml) and dry pyridine (0.15 ml) and isobutyryl chloride (0.12 ml) were then added. After stirring for 1 h at room temperature, the reaction mixture was then diluted with HCl 3 N (50 ml) and extracted with ethyl acetate (50 ml), then the organic phase was washed with brine (50 ml). The organic layer was separated, dried, filtered and evaporated under vacuum to give a crude product which was crystallized (diethyl ether, 7 ml) to give the title compound (0.11 g) as a yellow solid. m.p. 102-103°.

후처리

  1. extractionextracted with ethyl acetate (50 ml)
  2. washthe organic phase was washed with brine (50 ml)
  3. customThe organic layer was separated
  4. customdried
  5. filtrationfiltered
  6. customevaporated under vacuum
  7. customto give a crude product which
  8. customwas crystallized (diethyl ether, 7 ml)

출처 및 근거

ORD 기록
ord-a3979d4e05dc4badb73fa6fce8d45f95
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479488B1

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