N-bromobutanimide → 1-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-

HRID 1018072

반응식

HRID 1018072 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH:13]([CH3:15])[CH3:14])=[CH:9][CH:8]=1)=[O:6].[Br:16]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.CC(N=NC(C#N)(C)C)(C#N)C>[Br:16][C:13]([C:10]1[CH:9]=[CH:8][C:7]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][Cl:1])=[CH:12][CH:11]=1)([CH3:15])[CH3:14]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 987444-Chloro-4'-isopropylbutyrophenone

생성물 1

HCID 100635791-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-수율 100.9%

시약·촉매·용매 2

HCID 6547Azobisisobutyronitrile촉매HCID 5943Carbon Tetrachloride용매

반응 조건

온도
85 °C

실험 절차

Dissolve 4-chloro-1-(4-isopropyl-phenyl)-butan-1-one (5.00 g, 22.2 mmol) and N-bromosuccinimide (4.1 g, 23.0 mmol) in carbon tetrachloride (25 mL) and add AIBN radical initiator (300 mg). Stir and maintain under a nitrogen atmosphere at 80-90° C. or optionally irradiate with a sunlamp until a vigorous exotherm occurs at which point momentarily remove until reflux subsides and then reapply the heat. Reflux for 30 minutes and add another potion of N-bromosuccinimide (100 mg) while maintaining reflux and reflux an additional 15 minutes. Cool to room temperature and precipitate the succinimide from the solution by allowing to stand overnight. Filter and wash the succinimide (2.25 g) with carbon tetrachloride (20 mL). Combine the filtrates and evaporate the solvent in vacuo to give the title compound as a yellow oil (6.80 g, 100%).

후처리

  1. customoptionally irradiate with a sunlamp until a vigorous exotherm
  2. custommomentarily remove
  3. temperatureuntil reflux subsides
  4. temperatureReflux for 30 minutes
  5. additionadd another potion of N-bromosuccinimide (100 mg)
  6. temperaturewhile maintaining
  7. temperaturereflux
  8. temperaturereflux an additional 15 minutes
  9. temperatureCool to room temperature
  10. customprecipitate the succinimide from the solution
  11. filtrationFilter
  12. washwash the succinimide (2.25 g) with carbon tetrachloride (20 mL)
  13. customCombine the filtrates and evaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-995e3d6976de4b818da0a55f60a693e4
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06479663B2

연결된 노트

불러오는 중…