Thiosemicarbazide → 4-Acetamido-3-iodobenzaldehyde thiosemicarbazone

HRID 1018785노트

반응식

HRID 1018785 반응식
[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][C:6]=1[I:13])(=[O:3])[CH3:2].[NH2:14][NH:15][C:16]([NH2:18])=[S:17]>[Ni]>[C:1]([NH:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[N:14][NH:15][C:16]([NH2:18])=[S:17])=[CH:7][C:6]=1[I:13])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 2723789ThiosemicarbazideHCID 229919464-Acetamido-3-iodobenzaldehyde2회

생성물 1

HCID 30022964-Acetamido-3-iodobenzaldehyde thiosemicarbazone

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

lodination of 4-aminobenzonitrile 30 with ICI produces 4-amino-3-iodobenzonitrile 31. Acetylatation of 4-amino-3-iodobenzonitrile 31 results in compound 32, which can be reduced with Raney nickel to form 4-acetamido-3-iodobenzaldehyde 33. Reaction of compound 33 with thiosemicarbazide yields 4-acetamido-3-iodobenzaldehyde thiosemicarbazone 34, as illustrated below.

출처 및 근거

ORD 기록
ord-be676d1fea384f6e9d5e6cdaad0777d4
출처 데이터셋
uspto-grants-2002_11
특허 번호
US06482982B1

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