Hippuric Acid → 2-Carboxymethylbenzaldehyde hippuric acid

HRID 1020010노트

반응식

HRID 1020010 반응식
[C:1]([CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])([OH:3])=[O:2].[C:13]([OH:25])(=[O:24])[CH2:14][NH:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].C([O-])(=O)C.[K+].C(OC(=O)C)(=O)C>O>[C:13]([OH:25])(=[O:24])[CH2:14][NH:15][C:16]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:17].[C:1]([CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])([OH:3])=[O:2]

참가 물질

6

반응물 4

HCID 464Hippuric AcidHCID 7918Acetic AnhydrideHCID 517044Potassium AcetateHCID 5289058Ortho-formylphenylacetic acid

생성물 1

HCID 866643832-Carboxymethylbenzaldehyde hippuric acid수율 83%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

2-Carboxymethylbenzaldehyde (4.9 g, and 30 mmoles) with hippuric acid (5.9 g, 33 moles) and potassium acetate (2.94 g, 30 mmoles) were added to acetic anhydride (14.2 mls, 150 mmoles) and the reaction heated (100° C.) for 4 hours. To the cooled reaction was added water (100 mls) and stirred overnight. The resulting solid was collected by filtration and washed with water and dried (7.6 g, 83% yield).

후처리

  1. customTo the cooled reaction
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with water
  4. customdried (7.6 g, 83% yield)

출처 및 근거

ORD 기록
ord-4a4960fcc1c545198d1acb95e8f49687
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08716302B2

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