Formamide → HCID 86639522, 화합물

HRID 1022399노트

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HRID 1022399 반응식
[CH:1]([NH2:3])=[O:2].[H-].[Na+].Cl[C:7]1[N:16]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([Cl:23])[CH:13]=2)[N:8]=1.O>CN(C=O)C>[Cl:23][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:3][CH:1]=[O:2])[N:16]=[C:15]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

6

반응물 4

HCID 713FormamideHCID 962WaterHCID 24758Sodium hydrideHCID 16282212,6-dichloro-4-phenylquinazoline

생성물 1

HCID 86639522HCID 86639522, 화합물수율 22.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 54 mg of dry formamide in DMF (5 ml) was added 48 mg of sodium hydride (60%), followed by stirring at room temperature for 30 minutes. To the reaction mixture was added 275 mg of 2,6-dichloro-4-phenylquinazoline (compound No. Ia1-3), followed by warming to 85° C. and further stirring for 3 hours. The resulting reaction solution was poured into 100 ml of water and extracted with ethyl acetate. The extract was concentrated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:3) to obtain 64 mg of the titled compound. Mp.252.1° C. 1H NMR: 7.59-7.66 (3H, m), 7.72-7.81 (3H, m), 7.88 (1H, d, J=8.8 Hz), 8.02 (1H, d, J=2.0 Hz), 8.37 (1H, br. d, J=10.4 Hz), 9.71 (1H, d, J=10.4 Hz).

후처리

  1. temperatureby warming to 85° C.
  2. stirringfurther stirring for 3 hours
  3. customThe resulting reaction solution
  4. extractionextracted with ethyl acetate
  5. concentrationThe extract was concentrated
  6. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:3)

출처 및 근거

ORD 기록
ord-123331fd33d1444195bd83ea4cc0fd61
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722580B2

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