Diethyl Ether → Pyridine-4-amidine hydrochloride

HRID 10237

반응식

HRID 10237 반응식
[Na].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)#[N:3].[Cl-:10].[NH4+:11].C(OCC)C>CO>[ClH:10].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=[NH:11])[NH2:3]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 75064-CyanopyridineHCID 25517Ammonium ChlorideHCID 5360545Sodium

생성물 1

HCID 2776844Pyridine-4-amidine hydrochloride수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of sodium (0.23 g) in methanol (40 ml) was added 4-cyanopyridine (10.62 g) at r.t. Stirring was continued for 6 h followed by the addition of ammoniumchloride (5.9 g) and stirring was continued for another 10 h. Then, diethylether (120 ml) was added and the precipitate was filtered off after 30 min and washed with diethylether (20 ml). The product was dried under high vacuum. 4-Amidino-pyridine hydrochloride (14.95 g) was obtained as a white powder.

후처리

  1. stirringstirring
  2. waitwas continued for another 10 h
  3. filtrationthe precipitate was filtered off after 30 min
  4. washwashed with diethylether (20 ml)
  5. customThe product was dried under high vacuum

출처 및 근거

ORD 기록
ord-eabe532b36c040a6b450ec034d5b8835
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094781B2

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