Hydrochloric Acid → Methyl (4-chloro-2-iodophenoxy)acetate
반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([I:9])=[C:6]([OH:8])[CH:7]=1.Br[CH2:11][C:12]([O:14][CH3:15])=[O:13].C(=O)([O-])[O-].[K+].[K+].[ClH:22]>C(#N)C>[Cl:22][C:3]1[CH:2]=[CH:7][C:6]([O:8][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[C:5]([I:9])[CH:4]=1참가 물질
6
실험 절차
A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound (5.75 g).
후처리
- temperaturewas heated
- temperatureunder reflux for 2 h
- extractionthe mixture was extracted with ether (three times)
- dry with materialThe organic extracts were dried (MgSO4)
- customevaporated
- custompurified by chromatography (silica, petrol-ether as eluent)
출처 및 근거
- ORD 기록
- ord-2a5de9f6bf3444e5a3bee329e61c8d6c
- 출처 데이터셋
- uspto-grants-2014_05
- 특허 번호
- US08722741B2
반응 노트
불러오는 중…