Hydrazine hydrate (1:1) → 3,3a,4,5,6,7-hexahydro-2H-indazole

HRID 1024349

반응식

HRID 1024349 반응식
O.[NH2:2]N.C[N:5]([CH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=O)C>CCCCO>[N:2]1[NH:5][CH2:7][CH:8]2[C:9]=1[CH2:10][CH2:11][CH2:12][CH2:13]2

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 858382-((Dimethylamino)methyl)cyclohexanone

생성물 1

HCID 593393383,3a,4,5,6,7-hexahydro-2H-indazole

시약·촉매·용매 1

HCID 2631-Butanol용매2회

실험 절차

Hydrazine hydrate (28.0 mL) was dissolved in n-BuOH (200 mL) and cooled in an ice bath. A solution of 2-dimethylaminomethyl-cyclohexanone (64.0 g) in n-BuOH (50 mL) was added dropwise, the mixture was slowly warmed and refluxed for 20 hours. The solvent was evaporated under reduced pressure.

후처리

  1. temperaturecooled in an ice bath
  2. temperaturethe mixture was slowly warmed
  3. temperaturerefluxed for 20 hours
  4. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e0d9f0912948409299d9943f1d60f40e
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722887B2

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