[Na:1].[F:2][C:3]([F:11])([S:7]([OH:10])(=[O:9])=[O:8])[C:4]([OH:6])=[O:5].[O:12]=[C:13]1[CH:20]2[CH2:21][C:16]3(O)[CH2:17][CH:18]([CH2:22][CH:14]1[CH2:15]3)[CH2:19]2.C(C1C=CC=CC=1)C.S(=O)(=O)(O)O>>[Na:1].[F:2][C:3]([F:11])([S:7]([OH:10])(=[O:9])=[O:8])[C:4]([O:6][C:18]12[CH2:22][CH:14]3[CH2:15][CH:16]([CH2:21][CH:20]([C:13]3=[O:12])[CH2:19]1)[CH2:17]2)=[O:5]To a mixture of 5.0 parts of sodium salt of difluorosulfoacetic acid (purity: 62.6%), 2.6 parts of 4-oxo-1-adamantanol and 100 parts of ethylbenzene, 0.6 part of concentrated sulfuric acid was added and the resultant solution was refluxed for 30 hours. The mixture was cooled and filtrated. The obtained solid was washed with tert-butyl methyl ether to obtain 5.5 parts of sodium salt of 4-oxo-1-adamantyl difluorosulfoacetate. The purity thereof was 35.6% according to 1H-NMR analysis.
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