Bromine → Ethyl 3-bromo-2-oxobutanoate

HRID 1028408

반응식

HRID 1028408 반응식
[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH2:6][CH3:7])[CH3:2].[Br:10]Br>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH:6]([Br:10])[CH3:7])[CH3:2]

참가 물질

4

반응물 2

HCID 24408BromineHCID 85195ethyl acetoacetate, sodium salt

생성물 1

HCID 11117285Ethyl 3-bromo-2-oxobutanoate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The 2-oxo-butyric acid ethyl ester prepared above was dissolved in chloroform (100 mL) and bromine (20.964 g, 131.19 mmol) was added dropwise at room temperature. The reaction mixture was allowed to stir for 18 h. Concentration of the reaction mixture under reduced pressure provided 12.0 g of the title compound as an orange oil. 1H NMR (CDCl3) δ 4.39 (q, 2H), 4.32 (q, 1H), 1.88 (d, 3H), 1.39 (t, 3H).

출처 및 근거

ORD 기록
ord-a3102cce8b0343389afa889c1c18dcc1
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08735588B2

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