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1-Methylpiperazine → N-(4-(8-(4-Methylpiperazin-1-yl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-ylamino)phenyl)benzamide

HRID 1029234
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인쇄 미리보기

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HRID 1029234 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[C:14]3[C:9](=[N:10][CH:11]=[CH:12][C:13]=3[NH:15][C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:30])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:18][CH:17]=3)[NH:8][C:7](=[O:31])[C:6]=2[CH:32]=1.CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C.[CH3:67][N:68]1[CH2:73][CH2:72][NH:71][CH2:70][CH2:69]1>O1CCOCC1.CC([O-])=O.CC([O-])=O.[Pd+2]>[CH3:67][N:68]1[CH2:73][CH2:72][N:71]([C:2]2[CH:3]=[CH:4][C:5]3[C:14]4[C:9](=[N:10][CH:11]=[CH:12][C:13]=4[NH:15][C:16]4[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:30])[C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)=[CH:18][CH:17]=4)[NH:8][C:7](=[O:31])[C:6]=3[CH:32]=2)[CH2:70][CH2:69]1
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참가 물질

6

반응물 3

HCID 531671-MethylpiperazineHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 44205715N-(4-(8-Chloro-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-ylamino)phenyl)benzamide

생성물 1

HCID 44205716N-(4-(8-(4-Methylpiperazin-1-yl)-6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-ylamino)phenyl)benzamide

시약·촉매·용매 2

HCID 167845
palladium(II) acetate
촉매
HCID 312751,4-Dioxane용매

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온도
100 °C

실험 절차

275 (44 mg, 0.10 mmol), Pd(OAc)2 (6 mg 0.02 mmol), X-Phos (19 mg, 0.04 mmol), and 1-methylpiperazine (0.02 mL, 0.20 mmol) were suspended in dioxane (3 mL), and stirred overnight at 100° C. for overnight. The crude reaction mixture purified via HP-LC to provide 276. LC-MS (M+H=505, obsd.=505).

후처리

  1. customThe crude reaction mixture
  2. custompurified via HP-LC

출처 및 근거

ORD 기록
ord-13ce798e32a5413994324b67321d710e
출처 데이터셋
uspto-grants-2014_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08735584B2

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