Hydrochloric Acid → 4-Phenylmethyl-2,3-thiomorpholinedione-2-oxime

HRID 1030472노트

반응식

HRID 1030472 반응식
[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][S:10][C:9]2=[CH:13][N+:14]([O-:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].C([OH:21])C.Cl>O>[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][S:10][C:13](=[N:14][OH:16])[C:9]2=[O:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 30243963-Benzyl-2-nitromethylene-thiazolidine

생성물 1

HCID 851863704-Phenylmethyl-2,3-thiomorpholinedione-2-oxime

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2.36 g (0.01 mol) of 3-phenylmethyl-2-nitromethylenethiazolidine are boiled under reflux in the mixture of 50 ml of 1N sodium hydroxide solution and 25 ml of ethanol until the dissolution of the starting substance (when, based on the TLC examination, no starting substance is detected in a sample taken from the reaction mixture). Then, the mixture is cooled, acidified by adding hydrochloric acid diluted to 1:1 with water (to a pH value of 1), the precipitated product is filtered off, washed with water and dried to give the title compound in a yield of 2,15 g (91%), m.p.: 225°-227° C.

후처리

  1. temperatureThen, the mixture is cooled
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-31ba42b11ab441dfbe9a2c3b3d10d5b8
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05106846

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