Hydrochloric Acid → (5-Fluoro-2-nitrophenyl)methanamine

HRID 1030531

반응식

HRID 1030531 반응식
O.NN.[F:4][C:5]1[CH:6]=[CH:7][C:8]([N+:23]([O-:25])=[O:24])=[C:9]([CH2:11][N:12]2C(=O)C3=CC=CC=C3C2=O)[CH:10]=1.Cl>C(O)C>[F:4][C:5]1[CH:6]=[CH:7][C:8]([N+:23]([O-:25])=[O:24])=[C:9]([CH:10]=1)[CH2:11][NH2:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 19820552N-(5-fluoro-2-nitrophenyl)methyl-phthalimide

생성물 1

HCID 22040333(5-Fluoro-2-nitrophenyl)methanamine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

85% Hydrazine hydrate (1.67 ml) was added to a suspension of N-(5-fluoro-2-nitrophenyl)methyl-phthalimide (7.1 g) in ethanol (90 ml). The reaction mixture was heated to reflux for 3 hours, then cooled to 40° C. Hydrochloric acid was added and stirring was continued at that temperature for a further hour; then the solvent was removed under vacuum. The residue was taken up in water and the solid which separated was discarded. The mother liquors were treated with 10% sodium hydroxide and extracted with diethyl ether. After evaporation of the solvent 3.5 g of title compound were obtained as a reddish oil.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 3 hours
  3. waitwas continued at that temperature for a further hour
  4. customthen the solvent was removed under vacuum
  5. customthe solid which separated
  6. additionThe mother liquors were treated with 10% sodium hydroxide
  7. extractionextracted with diethyl ether
  8. customAfter evaporation of the solvent 3.5 g of title compound
  9. customwere obtained as a reddish oil

출처 및 근거

ORD 기록
ord-4c59c47191424f8a97e69a74222fba5b
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05106851

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