Hydrochloric Acid → 2-(Isobutylamino)benzyl chloride hydrochloride

HRID 1030798

반응식

HRID 1030798 반응식
[CH2:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8]O)[CH:2]([CH3:4])[CH3:3].[ClH:14]>>[ClH:14].[CH2:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8][Cl:14])[CH:2]([CH3:4])[CH3:3]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 10130218Benzenemethanol, 2-[(2-methylpropyl)amino]-

생성물 1

HCID 148394362-(Isobutylamino)benzyl chloride hydrochloride수율 68%

반응 조건

온도
100 °C

실험 절차

In 190 ml of conc. hydrochloric acid was dissolved 19.1 g of 2-(isobutylamino)benzyl alcohol, and the solution was heated in a sealed tube at 100° C. for 40 min. The reaction mixture was stirred for 30 min. under chilling with ice and the precipitated crystals were collected by filtration. The collected crystals were washed successively with hydrochloric acid and acetone and dried to give 16.9 g (yield: 68%) of 2-(isobutylamino)benzyl chloride hydrochloride as a white crystalline product.

후처리

  1. temperatureunder chilling with ice
  2. filtrationthe precipitated crystals were collected by filtration
  3. washThe collected crystals were washed successively with hydrochloric acid and acetone
  4. customdried

출처 및 근거

ORD 기록
ord-d7d07fa9f7ad4a61a7f7e61ebfa84079
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05106976

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