Aluminum(III) Chloride → 2,3-Dichloro-4-hydroxy-N-n-butylaniline

HRID 1031138

반응식

HRID 1031138 반응식
[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([O:14]C)[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8].[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C(Cl)Cl>[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([OH:14])[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

4

반응물 2

HCID 6451240Aluminum(III) ChlorideHCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

생성물 1

HCID 198144102,3-Dichloro-4-hydroxy-N-n-butylaniline

시약·촉매·용매 1

HCID 65911,1,2,2-Tetrachloroethane용매

실험 절차

To a stirred solution of 2,3-dichloro-4-methoxy-N-n-butylaniline (8.5 g) in 1,1,2,2-tetrachloroethane (80 ml) is added anhydrous aluminium chloride (8.5 g), and the mixture is refluxed for about 40 hours. The resulting mixture is poured into ice/water (about 500 ml), and the precipitated material is extracted twice with methylene chloride. The combined extracts are dried and evaporated in vacuo to give the title compound as a heavy oil.

후처리

  1. temperaturethe mixture is refluxed for about 40 hours
  2. extractionthe precipitated material is extracted twice with methylene chloride
  3. customThe combined extracts are dried
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-8be0f6bcc64f42ad86b8d7d36b652ad5
출처 데이터셋
uspto-grants-1992_04
특허 번호
US05109009

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