Hydrochloric Acid → 4,4'-Dimethoxybenzophenone O-(3-carboxy-2-methoxyiminopropyl) oxime

HRID 1031646노트

반응식

HRID 1031646 반응식
C([O:3][C:4]([CH2:6][C:7](=[N:28][O:29][CH3:30])[CH2:8][O:9][N:10]=[C:11]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)=[O:5])C.[OH-].[Na+].Cl>CO>[C:4]([CH2:6][C:7](=[N:28][O:29][CH3:30])[CH2:8][O:9][N:10]=[C:11]([C:20]1[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=1)[C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=1)([OH:5])=[O:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 538534414,4'-Dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime

생성물 1

HCID 540003984,4'-Dimethoxybenzophenone O-(3-carboxy-2-methoxyiminopropyl) oxime수율 98.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4.14 g of the 4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime as obtained in Example 30 was dissolved in 20 ml of methanol and 3 ml of a 5 N aqueous solution of caustic soda was added thereto. The obtained mixture was stirred at room temperature for five hours. After the completion of the reaction, the reaction mixture was acidified with diluted hydrochloric acid and extracted with ethyl acetate. Thus 3.8 g of the title compound was obtained in the form of a colorless oily product.

후처리

  1. customAfter the completion of the reaction
  2. extractionextracted with ethyl acetate

출처 및 근거

ORD 기록
ord-2a560aa9970b4bea8b2df4cfdb15f811
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04954523

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