2-(7-nitro-1H-indazol-4-yl)acetonitrile → 2-(7-amino-1H-indazol-4-yl)acetonitrile

HRID 1032544

반응식

HRID 1032544 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:13][C:14]#[N:15])=[C:8]2[C:12]=1[NH:11][N:10]=[CH:9]2)([O-])=O>O1CCCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:13][C:14]#[N:15])=[C:8]2[C:12]=1[NH:11][N:10]=[CH:9]2

참가 물질

4

반응물 1

HCID 136293082-(7-nitro-1H-indazol-4-yl)acetonitrile

생성물 1

HCID 193544342-(7-amino-1H-indazol-4-yl)acetonitrile수율 87.8%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

20.2 g of 2-(7-nitro-1H-indazol-4-yl)-acetonitrile in 750 ml of tetrahydrofuran is hydrogenated in the presence of 20.0 g of Raney nickel. The product is recrystallized from tetrahydrofuran/hexane, yielding 15.1 g of 2-(7-amino-1H-indazol-4-yl)acetonitrile, mp 164°-165° C.

후처리

  1. customThe product is recrystallized from tetrahydrofuran/hexane

출처 및 근거

ORD 기록
ord-eb4a0d8baa674734875fca2f76128da7
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04958026

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