Benzyl Chloride → Benzyl 2-benzyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate

HRID 1033296노트

반응식

HRID 1033296 반응식
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3].C[O:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1.[CH2:20](Cl)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[Mg]>O1CCCC1.CCOCC.Cl>[CH2:20]([CH:18]1[CH2:19][C:14](=[O:13])[CH:15]=[CH:16][N:17]1[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

8

반응물 4

HCID 7503Benzyl ChlorideHCID 10387Benzyl chloroformateHCID 692784-MethoxypyridineHCID 5462224Magnesium

생성물 1

HCID 19035856Benzyl 2-benzyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 3283Diethyl Ether용매3회HCID 8028Tetrahydrofuran용매2회

실험 절차

165 ml (1.16 mol) of benzyl chloroformate are added dropwise over the course of 20 minutes to a solution of 104 g (0.95 mol) of 4-methoxypyridine in 1 l of anhydrous tetrahydrofuran at -70° under argon. The thick beige suspension is then diluted with 200 ml of anhydrous tetrahydrofuran. The Grignard reagent prepared from 460 ml (1.46 mol) of a 3 molar solution of benzyl chloride in anhydrous ether and 35.5 g (1.46 mol) of magnesium turnings in 160 ml of anhydrous ether is then added dropwise to the reaction mixture over the course of 75 minutes, maintaining the temperature at -70°. After a further 10 minutes, it is allowed to warm to room temperature. It is diluted with 500 ml of ether, 900 ml of 4N hydrochloric acid are added dropwise, and the phases are separated. The organic phases are washed with water and brine, dried over magnesium sulfate and evaporated to dryness. The residue is chromatographed on silica gel with hexane/ethyl acetate (3:1). The title compound is obtained as a colourless viscous oil. TLC: hexane/ethyl acetate (1:3) Rf =0.7, IR: 1725, 1665, 1602 cm-1.

후처리

  1. additionis then added dropwise to the reaction mixture over the course of 75 minutes
  2. temperaturemaintaining the temperature at -70°
  3. additionare added dropwise
  4. customthe phases are separated
  5. washThe organic phases are washed with water and brine
  6. dry with materialdried over magnesium sulfate
  7. customevaporated to dryness
  8. customThe residue is chromatographed on silica gel with hexane/ethyl acetate (3:1)

출처 및 근거

ORD 기록
ord-0784a8337e2a4463bd8e47fc9af36ac0
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05310743

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