Hydrochloric Acid → 3-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

HRID 1033702

반응식

HRID 1033702 반응식
CC1C=CC(S(N(Cl)[Cl:12])(=O)=O)=CC=1.Cl.[CH3:15][CH:16]([CH2:28][CH3:29])[CH2:17][O:18][C:19](=[O:27])[C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1>C(O)(=O)C>[CH3:15][CH:16]([CH2:28][CH3:29])[CH2:17][O:18][C:19](=[O:27])[C:20]1[CH:21]=[CH:22][C:23]([OH:26])=[C:24]([Cl:12])[CH:25]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 68056Dichloramine-THCID 13530949Benzoic acid, 4-hydroxy-, 2-methylbutyl ester

생성물 1

HCID 230416823-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester수율 144.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

On the other hand, dichloramine T (28.0 g, 0.12 mol) was dissolved in acetic acid (450 ml), and hydrochloric acid (1.5 ml) was added. The resulting solution was dropwise added to a solution of the above p-hydroxybenzoic acid 2-methyl-butyl ester (50 g, 0.24 mol) dissolved in acetic acid (450 ml), followed by refluxing the mixture, allowing to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3-chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester (42 g) (b.p. 135°~138° C./4 mmHg).

후처리

  1. temperatureby refluxing the mixture
  2. distillationdistilling off acetic acid
  3. filtrationfiltering off

출처 및 근거

ORD 기록
ord-9628d6e533e344f2897cf7d0226e1cb9
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05312564

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